Loaded Potato Meatloaf Casserole is a comforting and hearty dish that’s perfect for family dinners. It combines the flavors of classic meatloaf with creamy potatoes and melted cheese. This casserole is not only delicious but also easy to prepare, making it a great choice for busy weeknights.

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Why Make This Recipe
There are many reasons to make Loaded Potato Meatloaf Casserole. First, it’s a one-dish meal, which means less cleanup! Second, the combination of meat and potatoes makes it filling and satisfying. Plus, it’s versatile—you can enjoy it as a cozy dinner or serve it for leftovers during the week. Families love it, and it’s sure to please even the pickiest eaters.
How to Make Loaded Potato Meatloaf Casserole
Ingredients:
- 2 pounds ground beef
- 1 cup breadcrumbs
- 2 large eggs
- 4 large potatoes, peeled and diced
- 1 cup shredded cheddar cheese
- 1/2 cup sour cream
- 1/2 cup milk
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- Salt and pepper to taste
Directions:
- Preheat the oven to 350°F (175°C).
- In a large bowl, mix the ground beef, breadcrumbs, eggs, garlic powder, onion powder, salt, and pepper until well combined.
- In a separate bowl, combine the diced potatoes, sour cream, milk, and half of the cheddar cheese.
- Layer the meat mixture in the bottom of a greased casserole dish.
- Spread the potato mixture on top of the meat layer.
- Top with the remaining cheddar cheese.
- Cover with aluminum foil and bake for 45 minutes.
- Remove the foil and bake for an additional 15 minutes until the cheese is bubbly and golden.
- Let rest for 10 minutes before serving.
How to Serve Loaded Potato Meatloaf Casserole
Serve Loaded Potato Meatloaf Casserole warm from the oven. It pairs well with a side salad or steamed vegetables for a complete meal. Cut it into squares to serve and enjoy every delicious bite.
How to Store Loaded Potato Meatloaf Casserole
If you have leftovers, store them in an airtight container in the refrigerator. It will stay good for up to 3-4 days. You can also freeze portions for longer storage. Just make sure to wrap it tightly and label it with the date.
Tips to Make Loaded Potato Meatloaf Casserole
- For extra flavor, you can add your favorite seasonings or herbs to the meat mixture.
- If you like a crispy top, broil the casserole for a few minutes after baking it.
- Try adding some cooked bacon bits or green onions for an extra loaded flavor.
Variation
You can easily customize this casserole by using ground turkey or chicken instead of beef. For a vegetarian option, try using plant-based ground meat and adding vegetables like bell peppers or mushrooms to the mix.
FAQs
1. Can I use sweet potatoes instead of regular potatoes?
Yes, sweet potatoes would work well in this recipe. They will add a different flavor and a bit of sweetness.
2. Can I make this casserole ahead of time?
Yes, you can assemble the casserole a day in advance. Just cover it and store it in the refrigerator until you are ready to bake it.
3. What should I serve with Loaded Potato Meatloaf Casserole?
You can serve it with a simple side salad, roasted vegetables, or even some crusty bread to soak up the delicious flavors.

Loaded Potato Meatloaf Casserole
Ingredients
For the meat mixture
- 2 pounds ground beef
- 1 cup breadcrumbs
- 2 large eggs
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- Salt and pepper to taste
For the potato layer
- 4 large potatoes, peeled and diced
- ½ cup sour cream
- ½ cup milk
- 1 cup shredded cheddar cheese divided
Instructions
Preparation
- Preheat the oven to 350°F (175°C).
- In a large bowl, mix the ground beef, breadcrumbs, eggs, garlic powder, onion powder, salt, and pepper until well combined.
- In a separate bowl, combine the diced potatoes, sour cream, milk, and half of the cheddar cheese.
Assembly & Baking
- Layer the meat mixture in the bottom of a greased casserole dish.
- Spread the potato mixture on top of the meat layer.
- Top with the remaining cheddar cheese.
- Cover with aluminum foil and bake for 45 minutes.
- Remove the foil and bake for an additional 15 minutes until the cheese is bubbly and golden.
- Let rest for 10 minutes before serving.