If you’re looking for a comfort food that combines two favorites into one delicious dish, then Mac and Cheese Meatloaf Casserole is the perfect recipe for you! This hearty meal brings together the classic flavors of meatloaf and the creamy goodness of macaroni and cheese, making it a hit for both kids and adults alike. Get ready to dig into a warm, cheesy, and meaty delight!

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Why Make This Recipe
This recipe is great for many reasons. First, it’s filling and satisfying, perfect for family dinners or get-togethers. Second, it’s easy to prepare and requires minimal cooking skills, so everyone can give it a try. Lastly, you can customize it with your favorite cheeses or spices, making it a versatile dish that can suit different tastes.
How to Make Mac and Cheese Meatloaf Casserole
Making Mac and Cheese Meatloaf Casserole is simple and fun. Here’s a breakdown of the necessary ingredients and step-by-step directions for creating this delicious meal.
Ingredients
- 1 lb ground beef
- 1/2 cup breadcrumbs
- 1/4 cup milk
- 2 cups mac and cheese (prepared)
- 1/2 cup shredded cheddar cheese
- 1/4 cup ketchup
- 1 tsp garlic powder
- 1 tsp onion powder
- Salt and pepper to taste
Directions
- Preheat your oven to 375°F (190°C).
- In a large bowl, combine the ground beef, breadcrumbs, milk, garlic powder, onion powder, salt, and pepper. Mix well.
- In a greased casserole dish, spread half of the prepared mac and cheese as the base layer.
- Form the meat mixture into a loaf shape and place it on top of the mac and cheese.
- Spread the remaining mac and cheese on top of the meatloaf, then sprinkle with shredded cheddar cheese.
- Drizzle the ketchup over the top.
- Bake in the preheated oven for 30-35 minutes until the meatloaf is cooked through.
- Let it cool slightly before slicing and serving.
How to Serve Mac and Cheese Meatloaf Casserole
Once your casserole is ready, slice it into portions and serve it hot. It pairs wonderfully with a side salad or some garlic bread. This meal can also be served as a stand-alone dish, giving you all the comfort you need.
How to Store Mac and Cheese Meatloaf Casserole
If you have leftovers, store them in an airtight container in the refrigerator. They will last for about 3-4 days. For longer storage, you can freeze the casserole. Just make sure to wrap it well, and it should be good for about 2-3 months.
Tips to Make Mac and Cheese Meatloaf Casserole
- Add your favorite spices for extra flavor, such as Italian seasoning or paprika.
- You can use ground turkey or chicken instead of beef for a lighter version.
- For an extra cheesy topping, mix in some parmesan cheese with the cheddar.
Variation
For a vegetarian option, substitute the ground beef with lentils or a plant-based meat alternative. You can also add some cooked vegetables to the meat mixture to boost the nutrition.
FAQs
1. Can I make this recipe ahead of time?
Yes! You can prepare it in advance and store it in the fridge until you’re ready to bake it.
2. What type of macaroni and cheese should I use?
You can use homemade mac and cheese or your favorite store-bought version; just make sure it’s prepared before using it in the casserole.
3. Can I add other ingredients?
Absolutely! Feel free to mix in cooked bacon bits, sautéed onions, or any other ingredients you enjoy. Just keep the ratios in mind to maintain the texture of the meatloaf.

Mac and Cheese Meatloaf Casserole
Ingredients
For the meat mixture
- 1 lb ground beef Can substitute with ground turkey or chicken for a lighter version.
- ½ cup breadcrumbs
- ¼ cup milk
- 1 tbsp garlic powder
- 1 tbsp onion powder
- Salt and pepper to taste Salt and pepper
For the casserole
- 2 cups mac and cheese (prepared) Store-bought or homemade.
- ½ cup shredded cheddar cheese For topping.
- ¼ cup ketchup For drizzling on top.
Instructions
Preparation
- Preheat your oven to 375°F (190°C).
- In a large bowl, combine ground beef, breadcrumbs, milk, garlic powder, onion powder, salt, and pepper. Mix well.
Assembly
- In a greased casserole dish, spread half of the prepared mac and cheese as the base layer.
- Form the meat mixture into a loaf shape and place it on top of the mac and cheese.
- Spread the remaining mac and cheese on top of the meatloaf, then sprinkle with shredded cheddar cheese.
- Drizzle ketchup over the top.
Baking
- Bake in the preheated oven for 30-35 minutes until the meatloaf is cooked through.
Serving
- Let it cool slightly before slicing and serving.